Query   'N-terminal Integrin beta subunit'  matched   6 Records

Record No : 1

Instance ID10812
Regular ExpressionRGD
Motif InstanceRGD
Bait Uniprot AccessionP21404
Bait Uniprot IdentifierPOLG_CXA9
Bait Gene NameNot Available
Bait OrganismCoxsackievirus A9 (strain Griggs)
Sequence Position858-860
Critical ResiduesUnknown
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)Competition binding; Solid phase assay; Fluorescence-activated cell sorting
Interaction ID20812
Interacting DomainN-terminal Integrin beta subunit
Disease Association(s)Coxsackie virus infection
Inhibitor(s)Unknown
Reference(s)15194773
CommentsThe Integrin binding RGD motif in VP1 capsid protein of Coxsackievirus A9 (CAV9) that mediates binding to the human Integrin beta-6 (ITGB6)

Record No : 2

Instance ID10813
Regular ExpressionRGD
Motif InstanceRGD
Bait Uniprot AccessionQ66578
Bait Uniprot IdentifierPOLG_HPE1H
Bait Gene NameNot Available
Bait OrganismHuman parechovirus 1 (strain Harris) (HPeV-1) (Echovirus 22)
Sequence Position764-766
Critical ResiduesUnknown
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)Competition binding; Peptide blocking assay
Interaction ID20813
Interacting DomainN-terminal Integrin beta subunit
Disease Association(s)Human parechovirus (HPEV) infection
Inhibitor(s)Unknown
Reference(s)20554778
CommentsThe C-terminal RGD motif in the Human parechovirus (HPEV) capsid protein VP1 that mediates binding to the human Integrin beta-6 (ITGB6)

Record No : 3

Instance ID10814
Regular ExpressionRGD
Motif InstanceRGD
Bait Uniprot AccessionP03305
Bait Uniprot IdentifierPOLG_FMDVO
Bait Gene NameNot Available
Bait OrganismFoot-and-mouth disease virus (isolate Bovine/Germany/O1Kaufbeuren/1966 serotype O) (FMDV)
Sequence Position869-871
Critical ResiduesUnknown
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)Competition binding
Interaction ID20814
Interacting DomainN-terminal Integrin beta subunit
Disease Association(s)Hand-foot-and-mouth disease (HFMD)
Inhibitor(s)Unknown
Reference(s)7533862
CommentsThe Integrin binding RGD motif in VP1 capsid protein of foot-and-mouth disease virus (FMDV) that mediates binding to the Human Integrin beta-3 (ITGB3)

Record No : 4

Instance ID10815
Regular ExpressionRGD
Motif InstanceRGD
Bait Uniprot AccessionP21815
Bait Uniprot IdentifierSIAL_HUMAN
Bait Gene NameIBSP
Bait OrganismHomo sapiens (Human)
Sequence Position286-288
Critical ResiduesP1; P2; P3
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)Mutation analysis
Interaction ID20815
Interacting DomainN-terminal Integrin beta subunit
Disease Association(s)Cancer
Inhibitor(s)Unknown
Reference(s)10785511
CommentsThe Integrin binding RGD motif in Human Integrin-binding Bone sialoprotein (BSP) that mediates binding to the Human Integrin beta-3 (ITGB3)

Record No : 5

Instance ID10816
Regular ExpressionRGD
Motif InstanceRGD
Bait Uniprot AccessionP10451
Bait Uniprot IdentifierOSTP_HUMAN
Bait Gene NameSPP1
Bait OrganismHomo sapiens (Human)
Sequence Position159-161
Critical ResiduesUnknown
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)Mutation analysis; Pull down(GST tag)
Interaction ID20816
Interacting DomainN-terminal Integrin beta subunit
Disease Association(s)Cancer
Inhibitor(s)Unknown
Reference(s)8910476
CommentsHuman Osteopontin N-terminal domain contains the RGD motif that mediates binding to Human Integrin beta-1 (ITGB1)

Record No : 6

Instance ID12040
Regular ExpressionRGD
Motif InstanceRGD
Bait Uniprot AccessionQ77UU3
Bait Uniprot IdentifierQ77UU3_HHV8
Bait Gene NameORF8
Bait OrganismHuman herpesvirus 8 (HHV-8) (Kaposi's sarcoma-associated herpesvirus)
Sequence Position27-29
Critical ResiduesUnknown
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)Sequence based prediction; Competition binding
Interaction ID22040
Interacting DomainN-terminal Integrin beta subunit
Disease Association(s)Kaposi's sarcoma
Inhibitor(s)Unknown
Reference(s)12584338, 24814923
CommentsHuman herpesvirus 8 (HHV-8) or Kaposi's sarcoma-associated herpesvirus envelope glycoprotein B binds beta 1 integrin via its RGD motif, which may play roles in the infection of target cells and in Kaposi's sarcoma pathogenesis


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For queries, suggestions and submission of novel motifs please contact Dr. Sudipto Saha (ssaha4@jcbose.ac.in)